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Abstract Title:

Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment.

Abstract Source:

Life Sci. 2019 Mar 22. Epub 2019 Mar 22. PMID: 30910646

Abstract Author(s):

Marika Premoli, Francesca Aria, Sara Anna Bonini, Giuseppina Maccarinelli, Alessandra Gianoncelli, Silvia Della Pina, Simone Tambaro, Maurizio Memo, Andrea Mastinu

Article Affiliation:

Marika Premoli

Abstract:

The pharmacological research on the Cannabis sativa-derived compounds has never terminated. Among the phytocannabinoids without psychotropic effects, the prevalent one in Cannabis is cannabidiol (CBD). Although CBD was initially considered a type 2 cannabinoid receptor (CB2R) antagonist, it did not show a good cannabinoidergic activity. Furthermore, heterogeneous results were obtained in experimental animal models of anxiety disorders, psychotic stages and neurodegenerative diseases. Recently, CBD has been authorized by the FDA to treat some rare forms of epilepsy and many trials have begun for the treatment of autism spectrum disorders. This review aims to clarify the pharmacological activity of CBD and its multiple therapeutic applications. Furthermore, critical and conflicting results of the research on CBD are discussed with a focus on promising future prospects.

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Sayer Ji
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