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Abstract Title:

Cannabidiol attenuates mechanical allodynia in streptozotocin-induced diabetic rats via serotonergic system activation through 5-HT1A receptors.

Abstract Source:

Brain Res. 2019 Mar 18. Epub 2019 Mar 18. PMID: 30898678

Abstract Author(s):

Carlos Henrique Alves Jesus, Daiany Darlly Bello Redivo, Aléxia Thamara Gasparin, Bruna Bittencourt Sotomaior, Milene Cristina de Carvalho, Karina Genaro, Antonio Waldo Zuardi, Jaime Eduardo Cecílio Hallak, José Alexandre Crippa, Janaina Menezes Zanoveli, Joice Maria da Cunha

Article Affiliation:

Carlos Henrique Alves Jesus

Abstract:

Most diabetic patients describe moderate to severe pain symptoms whose pharmacological treatment is palliative and poorly effective. Cannabidiol (CBD) has shown promising results in painful conditions. Then, we aimed to investigate the potential antinociceptive effect of CBD over the mechanical allodynia in streptozotocin-induced diabetic (DBT) rats, as well as its involved mechanisms. Wistar adult male diabetic rats were treated acutely or sub-chronically (for 14 days) with CBD (0.1, 0.3 or 3 mg/Kg, intraperitoneal; i.p.) and had their mechanical threshold assessed using the electronic Von Frey. Acute treatment with CBD (at doses of 0.3 and 3 mg/Kg) exerted a significant anti-allodynic effect, which is not associated with locomotor impairment. The antinociceptive effect of CBD (3 mg/Kg) was not altered by the pre-treatment with CBor CBreceptor antagonists (AM251 and AM630; respectively; both at a dose of 1 mg/kg, i.p.) nor by glycine receptor antagonist (strychnine hydrochloride, 10μg/rat, intrathecal, i.t.). However, this effect was completely prevented by the pre-treatment with the selective 5-HTreceptor antagonist WAY 100135 (3μg/rat, i.t.). Sub-chronic treatment with CBD (0.3 or 3 mg/Kg) induced a sustained attenuation of the mechanical allodynia in DBT rats. DBT rats presented significantly lower spinal cord levels of serotonin, which was prevented by the daily treatment with CBD (0.3 mg/Kg). Taken together, our data suggest that CBD may be effective in the treatment of painful diabetic neuropathy and this effect seems to be potentially mediated by the serotonergic system activation through 5-HTreceptors.

Study Type : Animal Study

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