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Abstract Title:

Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing.

Abstract Source:

J Wound Care. 2016 Dec 2 ;25(12):732-739. PMID: 27974009

Abstract Author(s):

M Buzzi, F de Freitas, M de Barros Winter

Article Affiliation:

M Buzzi

Abstract:

OBJECTIVE: Non-healing venous leg ulcers (VLUs) have a significant effect on patients' quality of life and substantially increase expenditures in health-care systems. The aim of this study was to evaluate the clinical efficacy of the Calendula officinalis extract, Plenusdermax, in the treatment of VLUs.

METHOD: Patients treated with Calendula officinalis extract (n=38) and control patients (n=19) were evaluated every two weeks for 30 weeks or until their ulcers healed. Assessments included determination of the wound area by planimetry, infection control, and evaluation of the clinical aspects of the wounds. The percentage of healing velocity per week (%HVw), taking the initial area at baseline into account, was also determined.

RESULTS: The proportion of the treatment patients achieving complete epithelialisation was 72 % and 32 % in the treatment and control groups, respectively. The average healing time was approximately 12 weeks in the treatment group and 25 % in control patients. Patients with ulcers treated with Calendula officinalis extract had a significant 4-fold increase in percentage healing velocity per week, 7.4 %, compared with 1.7 % in the control group. No adverse events were observed during the Calendula officinalis extract treatment.

CONCLUSION: Our findings indicate that Calendula officinalis extract is an effective treatment for VLUs.

DECLARATION OF INTEREST: The authors have no conflict of interest.

Study Type : Human Study

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