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Abstract Title:

Chemical composition and anti-inflammatory activity of Chamaecyparis obtusa f.formosana wood essential oil from Taiwan.

Abstract Source:

Nat Prod Commun. 2014 May ;9(5):723-6. PMID: 25026733

Abstract Author(s):

Tzu-Chao Chien, Sheng-Fong Lo, Chen-Lung Ho

Article Affiliation:

Tzu-Chao Chien

Abstract:

Chamaecyparis obtusa Siebold&Zucc. f.formosana Hayata (Cupressaceae) is one of the treasured conifers in Taiwan. In this study, the wood essential oil of the species was extracted and its anti-inflammatory bioactivities analyzed. The composition analysis of the essential oil yielded a total of 57 compounds with alpha-terpineol (19.4%), tau-muurolol (16.9%), borneol (16%), and alpha-cadinol (10.9%) predominating. The anti-inflammatory assays of the essential oil suggest that C obtusa f. formnosana wood oil has no cytotoxicity, and was capable of inhibiting the expressions of tumor necrosis factor (TNF-alpha), IL-6, IL-1, pro IL-1beta, NO, iNOS, and NLRP3 in murine macrophage cells. It was unable, however, to inhibit the expression of COX-2. Further investigation of the effect of the essential oil on the cellular signal transduction indicated that it was capable of inhibiting ERKI/2, JNKI/2 and p38; it also showed excellent inhibition against ROS. Thus, the overall results indicated that C. obtusa f.formnosana wood oil had very good anti-inflammatory efficacies.

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