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Article Publish Status: FREE
Abstract Title:

andPostprandial Glycemic Activity ofPeel Flour.

Abstract Source:

Pharmacogn Mag. 2017 Oct-Dec;13(52):613-616. Epub 2017 Nov 13. PMID: 29200722

Abstract Author(s):

José Miguel Flores-Fernández, Carla Patricia Barragán-Álvarez, Nestor Emmanuel Díaz-Martínez, Socorro Villanueva-Rodríguez, Eduardo Padilla-Camberos

Article Affiliation:

José Miguel Flores-Fernández

Abstract:

Background: Previous studies ofspp. peel have shown hypoglycemic and antioxidant activities.has been studied for its therapeutic properties. Diabetes mellitus (DM) is a health problem in Mexico and worldwide, that takes a vital importance due to its high incidence. Recently, scientists have searched natural sources to control the disease.

Materials and Methods: In this study, we evaluated thehypoglycemic activity andpostprandial glycemic effect ofpeel flour by glucose adsorption and retardation assays as well as postprandial serum glucose levels using a group of female Balb-c mice, respectively.

Results: peel flour showed a glucose adsorption capacity of 16.58 mM, having a similar effect regarding the positive control. The glucose diffusion in the dialysate was elevated, with a glucose dialysis retardation index of 33.79% in a period of 3 h, showing similar results to positive control. Postprandial serum glucose levels in the animal group treated withpeel flour showed a glucose level of 41.4 mg/dL, being this value significantly lower than negative control group and similar to positive control. Toxicity tests showed good tolerance to the dose of 2000 mg/kg.

Conclusion: peel flour could act as a source of functional compounds for the control of DM.

SUMMARY: peel flour showed a glucose adsorption capacity similar to the positive controlThe glucose diffusion in the dialysate was elevated, showing similar results to positive controlPostprandial serum glucose levels in the animal group treated withpeel flour showed a glucose level significantly lower than negative control group and similar to positive controlToxicity tests showed good tolerancepeel flour could act as a source of functional compounds for the control of diabetes mellitus.CIATEJ: Center for Research and Assistance in Technology and Design of Jalisco; DM: Diabetes mellitus; FGC: Final glucose concentration; GDRI: Glucose dialysis retardation index; IGC: Initial glucose concentration; OECD: Organization for Economic Cooperation and Development.

Study Type : Animal Study, In Vitro Study
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