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Abstract Title:

Ameliorative effects of black tea extract on aflatoxin-induced lipid peroxidation in the liver of mice.

Abstract Source:

Food Chem Toxicol. 2005 Jan;43(1):99-104. PMID: 15582201

Abstract Author(s):

Anamika Choudhary, R J Verma

Article Affiliation:

Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380 009, India.

Abstract:

We have evaluated the ameliorative effect of black tea extract on aflatoxin-induced lipid peroxidation in the liver of mice. Adult male albino mice were orally administered with 25 and 50 microg of aflatoxin in 0.2 ml olive oil/animal/day for 30 days. Results revealed dose-dependent and significantly (p<0.05) higher lipid peroxidation in the liver of aflatoxin-treated mice than that of vehicle control. As compared with vehicle control, the levels of non-enzymatic antioxidants such as glutathione and ascorbic acid, as well as the enzymatic antioxidants such as superoxide dismutase, glutathione peroxidase and catalase were significantly (p<0.05) lowered in the liver of aflatoxin-treated mice. Oral administration of two percent aqueous black tea extract along with aflatoxin for 30 days (groups 6 and 7) caused significant (p<0.05) amelioration in aflatoxin-induced lipid peroxidation by increasing significantly (p<0.05) the activities of enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and contents of non-enzymatic (glutathione and ascorbic acid) antioxidants in the liver of mice as compared with those given aflatoxin alone (groups 4 and 5). Thus, oral administration of black tea along with aflatoxin significantly (p<0.05) ameliorates aflatoxin-induced lipid peroxidation in the liver of mice.

Study Type : Animal Study
Additional Links
Pharmacological Actions : Antioxidants : CK(14410) : AC(5758)

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