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Abstract Title:

Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum chloroform extract in animal models.

Abstract Source:

Yakugaku Zasshi. 2006 Nov;126(11):1171-8. PMID: 17077618

Abstract Author(s):

Zainul Amiruddin Zakaria, Hanan Kumar Gopalan, Hairani Zainal, Nur Hidayu Mohd Pojan, Nur Atiqah Morsid, Anwariah Aris, Mohd Roslan Sulaiman

Abstract:

AIM: The present study was carried out to evaluate the antinociceptive, anti-inflammatory and antipyretic effects of chloroform extract of Solanum nigrum leaves using various animal models. METHODS: The extract was prepared by soaking (1:20; w/v) the air-dried powdered leaves (20 g) in chloroform for 72 hrs followed by evaporation (40 degrees C) under reduced pressure to dryness (1.26 g) and then dissolved (1:50; w/v) in dimethylsulfoxide (DMSO). The supernatant, considered as the stock solution with dose of 200 mg/kg, was diluted using DMSO to 20 and 100 mg/kg, and all doses were administered (s.c.; 10 ml/kg) in mice/rats 30 min prior to tests. RESULTS: The extract exhibited significant (p<0.05) antinociceptive activity when assessed using the abdominal constriction, hot plate and formalin tests. The extract also produced significant (p<0.05) anti-inflammatory and antipyretic activities when assessed using the carrageenan-induced paw edema and brewer's yeast-induced pyrexia tests. Overall, the activities occurred in a dose-independent manner. CONCLUSION: The present study demonstrated that the lipid-soluble extract of S. nigrum leaves possessed antinociceptive, anti-inflammatory and anti-pyretic properties and confirmed the traditional claims.

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Sayer Ji
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