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Abstract Title:

Analogues of the epoxy resin monomer diglycidyl ether of bisphenol F: effects on contact allergenic potency and cytotoxicity.

Abstract Source:

Chem Res Toxicol. 2012 Nov 19 ;25(11):2469-78. Epub 2012 Oct 9. PMID: 22998141

Abstract Author(s):

Niamh M O'Boyle, Tamara Delaine, Kristina Luthman, Andreas Natsch, Ann-Therese Karlberg

Article Affiliation:

Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy, University of Gothenburg, SE-412 96 Gothenburg, Sweden. oboyleni@tcd.ie

Abstract:

Diglycidyl ethers of bisphenol A (DGEBA) and bisphenol F (DGEBF) are widely used as components in epoxy resin thermosetting products. They are known to cause occupational and nonoccupational allergic contact dermatitis. The aim of this study is to investigate analogues of DGEBF with regard to contact allergy and cytotoxicity. A comprehensive knowledge of the structural features that contribute to the allergenic and cytotoxic effects of DGEBF will guide the development of future novel epoxy resin systems with reduced health hazards for those coming into contact with them. It was found that the allergenic effects of DGEBF were dependent on its terminal epoxide groups. In contrast, it was found that the cytotoxicity in monolayer cell culture was dependent not only on the presence of epoxide groups but also on other structural features.

Study Type : Review
Additional Links
Problem Substances : Bisphenol F : CK(2) : AC(1)
Adverse Pharmacological Actions : Allergenic : CK(26) : AC(6), Cytotoxic : CK(89) : AC(53)

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