Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

n/a
Abstract Title:

Bifidobacterium longum subsp infantis CECT7210 supplemented formula reduces diarrhoea in healthy infants: a randomized controlled trial.

Abstract Source:

Pediatr Res. 2018 Mar 14. Epub 2018 Mar 14. PMID: 29538368

Abstract Author(s):

Joaquin Escribano, Natalia Ferré, Mariona Gispert-Llaurado, Veronica Luque, Carmen Rubio-Torrents, Marta Zaragoza-Jordana, Isabel Polanco, Francisco M Codoñer, Empar Chenoll, Mireia Morera, Jose Antonio Moreno Muñoz, Montserrat Rivero, Ricardo Closa-Monasterolo

Article Affiliation:

Joaquin Escribano

Abstract:

BACKGROUND: Intestinal microbiota of breast-fed infants is plenty of beneficial bifidobacteria. We aimed to determine whether an infant formula supplemented with probiotic Bifidobacterium longum subsp. infantis CECT7210 (B. infantis IM1®) is effective at reducing diarrhoea incidence in healthy term infants.

METHODS: Double-blinded, randomized, multicentre, controlled clinical trial, where formula-fed infants (<3 months) received an infant formula supplemented (Probiotic) or not (Control) with 10cfu/g of B. infantis IM1® over 12 weeks. Diarrhoeas, growth, digestive symptoms, stool bifidobacteria and microbiota were assessed.

RESULTS: 97 (Control) and 93 (Probiotic) infants were randomized, 78 (Control) and 73 (Probiotic) completed the 12 weeks follow-up. In the overall study period, a median of 0.29±1.07 and 0.05±0.28 diarrhoea events/infant was observed in the Control and Probiotic groups respectively (p=0.059). This trend to less diarrhoea episodes in the Probiotic group reached statistical significance at 8 weeks (0.12±0.47 vs. 0.0±0.0 events/infant, P=0.047). Constipation incidence washigher (OR 2.67 (1.09-6.50)) and stool frequency lower (2.0±1.0 vs. 2.6±1.3 stools/day, P=0.038) in the Control group after 4 weeks. No differences were found at other timepoins nor in other digestive symptoms, growth or formula intake.

CONCLUSIONS: A B. infantis IM1®-supplemented infant formula may reduce diarrhoea episodes; being safe, well tolerated and associated with lower constipation prevalence.Pediatric Research accepted article preview online, 14 March 2018. doi:10.1038/pr.2018.34.

Study Type : Human Study
Additional Links
Pharmacological Actions : Antidiarrheals : CK(110) : AC(20)

Print Options


Key Research Topics

Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.