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Abstract Title:

β-elemene increases the sensitivity of gastric cancer cells to TRAIL by promoting the formation of DISC in lipid rafts.

Abstract Source:

Cell Biol Int. 2018 Sep ;42(10):1377-1385. Epub 2018 Jul 23. PMID: 29957841

Abstract Author(s):

Ling Xu, Tianshu Guo, Xiujuan Qu, Xuejun Hu, Ye Zhang, Xiaofang Che, Huicong Song, Jing Gong, Rui Ma, Ce Li, Yibo Fan, Yanju Ma, Kezuo Hou, Peihong Wu, Hang Dong, Yunpeng Liu

Article Affiliation:

Ling Xu

Abstract:

β-Elemene, an anti-cancer drug extracted from traditional Chinese medicinal herb, showed anti-tumor effects on gastric cancer cells. Our previous studies reported gastric cancer cells are insensitive to TRAIL. However, whether β-elemene could enhance anti-cancer effects of TRAIL on gastric cancercells is unknown. In our present study, β-elemene prevented gastric cancer cell viability in dose-dependent manner, and when combined with TRAIL, obviously inhibited proliferation and promoted apoptosis in gastric cancer cells. Compared to β-elemene or TRAIL alone, treatment with β-elemene and TRAIL obviously promoted DR5 clustering as well as translocation of Caspase-8, DR5 and FADD into lipid rafts. This led to cleavage of Caspase-8 and the formation of death-inducing signaling complex (DISC) in lipid rafts. The cholesterol-sequestering agent nystatin partially reversed DR5 clustering andDISC formation, preventing apoptosis triggered by the combination of β-elemene and TRAIL. Our results suggest that β-elemene increases the sensitivity of gastric cancer cells to TRAIL partially by promoting the formation of DISC in lipid rafts.

Study Type : In Vitro Study

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