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Abstract Title:

Gastroprotective effect and antioxidant properties of different Laurus nobilis L. leaf extracts.

Abstract Source:

J Med Food. 2011 Feb 11. Epub 2011 Feb 11. PMID: 21314364

Abstract Author(s):

Ester Speroni, Rinaldo Cervellati, Stefano Dall'Acqua, Maria Clelia Guerra, Emanuela Greco, Paolo Govoni, Gabbriella Innocenti

Article Affiliation:

1 Department of Pharmacology, "G. Ciamician," University of Bologna , Bologna, Italy.

Abstract:

Abstract Laurus nobilis L. (Family Lauraceae) is an evergreen tree widely distributed in the Mediterranean area and Europe. It is used in folk medicine of different countries as a stomachic and carminative as well as in treatment of gastric diseases. Extracts obtained with different methods (methanol and chloroform) from laurel leaves were evaluated for their gastroprotective activities in the rat. The antioxidant capacity of the different extracts has been also measured in vitro. In order to confirm the activities investigated, histological observations were performed. The gastric damage was significantly reduced by all extracts administered. The more effective protection was produced by chloroformic and methanolic crude extracts. The results obtained after oral administration of L. nobilis leaf extracts are in good agreement with their antioxidant capacity, confirming the relationship between pharmacological efficacy and antiradical activity. Histological evidences confirm the results evaluated with the animal procedures.

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Sayer Ji
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