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Abstract Title:

Trypanocidal terpenoids from Laurus nobilis L.

Abstract Source:

Chem Pharm Bull (Tokyo). 2002 Nov;50(11):1514-6. PMID: 12419922

Abstract Author(s):

Nahoko Uchiyama, Keiji Matsunaga, Fumiyuki Kiuchi, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki

Article Affiliation:

Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.

Abstract:

Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 microM, respectively.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Trypanocidal Agents : CK(2) : AC(2)

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