Bay leaf contains constituents which exhibit trypanocidal activity. - GreenMedInfo Summary
Trypanocidal terpenoids from Laurus nobilis L.
Chem Pharm Bull (Tokyo). 2002 Nov;50(11):1514-6. PMID: 12419922
Graduate School of Pharmaceutical Sciences, Kyoto University, Japan.
Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 microM, respectively.