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Abstract Title:

Protective effects of the pyrolyzates derived from bamboo against neuronal damage and hematoaggregation.

Abstract Source:

J Ethnopharmacol. 2010 Apr 21;128(3):594-9. Epub 2010 Feb 1. PMID: 20117201

Abstract Author(s):

Eui-Ju Hong, Eui-Man Jung, Geun-Shik Lee, Joo Youn Kim, Ki-Jeong Na, Mi-Jin Park, Ha-Young Kang, Kyung-Chul Choi, Yeon Hee Seong, In-Gyu Choi, Eui-Bae Jeung

Article Affiliation:

Department of Veterinary Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.

Abstract:

ETHNOPHARMACOLOGICAL RELEVANCE: Bamboo species are thought to be originally from Central China, but are now found in many temperate and semi-tropical regions around the world. Although the extracts from bamboo may have antioxidant activities and anti-inflammatory effects, their exact biological activities have not been elucidated. AIM OF THE STUDY: Two biological activities of bamboo-derived pyrolyzates were investigated; the protective effects against N-methyl-d-aspartate (NMDA)-induced cell death in primary cultured cortical neuron and the anti-plasmin effects determined by using fibrin and fibrinogen degradation products (FDPs) assay. RESULTS: Treatment of neuronal cells with pyrolyzates of Phyllostachys pubescens, Phyllostachys nigra and Phyllostachys bambusoides resulted in restored cell viability when compared to untreated cells in an NMDA-induced neuronal cell death assay. In addition, cortical neurons treated with Phyllostachys pubescens and Phyllostachys nigra showed a reduction of apoptosis following exposure to NMDA, as determined by Hoechst 33342 staining. In addition, Phyllostachys nigra pyrolyzates also exhibited anti-plasmin action in a FDP assay. It is of interest to note that pyrolyzates exhibited activities of NMDA-receptor antagonist and antifebrin (ogen), since a combination of NMDA receptor antagonists, glucocorticosteroids, GABAergic drugs and heparin are useful for treatment in delayed postischemic injury. CONCLUSION: Our results indicate that the pyrolyzates derived from bamboo may have anti-apoptotic effects, and can be useful as a supplement for ischemic injury treatment.

Study Type : Animal Study

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Sayer Ji
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