Baicalein improves learning and memory dysfunction in D-gal induced aging rats. - GreenMedInfo Summary
Baicalein exerts beneficial effects in D-galactose induced aging rats through attenuation of inflammation and metabolic dysfunction.
Rejuvenation Res. 2017 May 26. Epub 2017 May 26. PMID: 28548620
Baicalein is a flavonoid isolated from the roots of Scutellaria baicalensis Georgi. This study aimed to ascertain the effects and potential underlying mechanisms of baicalein in D-galactose induced aging rat model by integration of behavior examination, biochemical detection and 1H NMR based metabolomic approach. Our findings suggest that baicalein significantly attenuated memory decline in D-galactose induced aging model, as manifested by increasing recognition index in novel object recognition test, shortening latency time and increasing platform crossings in morris water maze test. Baicalein significantly inhibited the releases of inflammatory mediators such as such as nitric oxide, interleukin-6, interleukin-1 beta, tumor necrosis factor-α in D-galactose induced aging model. Metabolomic study revealed that 10 endogenous metabolites in cerebral cortex were considered as potential biomarkers of baicalein for its protective effect. Further metabolic pathway analysis showed that the metabolic alterations were associated with alanine, aspartate and glutamate metabolism, glycine, serine and threonine metabolism, inositol phosphate metabolism and energy metabolism. These data indicate that baicalein improves learning and memory dysfunction in D-gal induced aging rats. This might be achieved through attenuation of inflammation and metabolic dysfunction.