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Abstract Title:

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid.

Abstract Source:

Naunyn Schmiedebergs Arch Pharmacol. 2016 Sep ;389(9):985-98. Epub 2016 Jun 17. PMID: 27314669

Abstract Author(s):

Francislaine Aparecida Dos Reis Lívero, Luisa Mota da Silva, Daniele Maria Ferreira, Larissa Favaretto Galuppo, Debora Gasparin Borato, Thiago Bruno Lima Prando, Emerson Luiz Botelho Lourenço, Regiane Lauriano Batista Strapasson, MariaÉlida Alves Stefanello, Maria Fernanda de Paula Werner, Alexandra Acco

Article Affiliation:

Francislaine Aparecida Dos Reis Lívero

Abstract:

Ethanol is a psychoactive substance highly consumed around the world whose health problems include gastric lesions. Baccharis trimera is used in folk medicine for the treatment of gastrointestinal disorders. However, few studies have evaluated its biological and toxic effects. To validate the popular use of B. trimera and elucidate its possible antiulcerogenic and cytotoxic mechanisms, a hydroethanolic extract of B. trimera (HEBT) was evaluated in models of gastric lesions. Rats and mice were used to evaluate the protective and antiulcerogenic effects of HEBT on gastric lesions induced by ethanol, acetic acid, and chronic ethanol consumption. The effects of HEBT were also evaluated in a pylorus ligature model and on gastrointestinal motility. The LD50 of HEBT in mice was additionally estimated. HEBT was analyzed by nuclear magnetic resonance, and a high-performance liquid chromatography fingerprint analysis was performed. Oral HEBT administration significantly reduced the lesion area and the oxidative stress induced by acute and chronic ethanol consumption. However, HEBT did not protect against gastric wall mucus depletion and did not alter gastric secretory volume, pH, or total acidity in the pylorus ligature model. Histologically, HEBT accelerated the healing of chronic gastric ulcers in rats, reflected by contractions of the ulcer base. Flavonoids and caffeoylquinic acids were detected in HEBT, which likely contributed to the therapeutic efficacy of HEBT, preventing or reversing ethanol- and acetic acid-induced ulcers, respectively. HEBT antiulcerogenic activity may be partially attributable to the inhibition of free radical generation and subsequent prevention of lipid peroxidation. Our results indicate that HEBT has both gastroprotective and curative activity in animal models, with no toxicity.

Study Type : Animal Study

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Sayer Ji
Founder of GreenMedInfo.com

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