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Article Publish Status: FREE
Abstract Title:

Screening for compounds with aromatase inhibiting activities from Atractylodes macrocephala Koidz.

Abstract Source:

Molecules. 2011 Apr 14 ;16(4):3146-51. Epub 2011 Apr 14. PMID: 21494203

Abstract Author(s):

Hai Jiang, Jing Shi, Yuanyuan Li

Article Affiliation:

Hai Jiang

Abstract:

Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I, atractylenolide II and atractylenolide III had inhibition ratios of 94.56± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Aromatase Inhibitors : CK(37) : AC(27)

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Sayer Ji
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