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Abstract Title:

Artemisinin triggers induction of cell-cycle arrest and apoptosis in Leishmania donovani promastigotes.

Abstract Source:

J Med Microbiol. 2007 Sep;56(Pt 9):1213-8. PMID: 17761485

Abstract Author(s):

Rupashree Sen, Samiran Bandyopadhyay, Avijit Dutta, Goutam Mandal, Sudipto Ganguly, Piu Saha, Mitali Chatterjee

Article Affiliation:

Department of Pharmacology, Institute of Postgraduate Medical Education&Research, 244 B Acharya J C Bose Road, Kolkata 700 020, India.

Abstract:

A major impediment to effective anti-leishmanial chemotherapy is the emergence of drug resistance, especially to sodium antimony gluconate, the first-line treatment for leishmaniasis. Artemisinin, a sesquiterpene lactone isolated from Artemisia annua, is an established anti-malarial compound that showed anti-leishmanial activity in both promastigotes and amastigotes, with IC(50) values of 160 and 22 microM, respectively, and, importantly, was accompanied by a high safety index (>22-fold). The leishmanicidal activity of artemisinin was mediated via apoptosis as evidenced by externalization of phosphatidylserine, loss of mitochondrial membrane potential, in situ labelling of DNA fragments by terminal deoxyribonucleotidyltransferase-mediated dUTP nick end labelling (TUNEL) and cell-cycle arrest at the sub-G(0)/G(1) phase. Taken together, these data indicate that artemisinin has promising anti-leishmanial activity that is mediated by programmed cell death and, accordingly, merits consideration and further investigation as a therapeutic option for the treatment of leishmaniasis.

Study Type : In Vitro Study

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