Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

Abstract Title:

Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats.

Abstract Source:

J Sci Food Agric. 2015 May 12. Epub 2015 May 12. PMID: 25965053

Abstract Author(s):

T O Ajiboye, H O Raji, A O Adeleye, N S Adigun, O B Giwa, O B Ojewuyi, A T Oladiji

Article Affiliation:

T O Ajiboye

Abstract:

BACKGROUND: The effect of Hibiscus sabdariffa calyx extract was evaluated in high-fructose induced metabolic syndrome rats. Insulin resistance, hyperglycemia, dyslipidemia and oxidative rout were induced in rats using high-fructose diet. High-fructose diet-fed rats were administered 100 and 200 mg/kg body weight of Hibiscus sabdariffa extract for 3 weeks, starting from the seventh week of high-fructose diet treatment.

RESULTS: High fructose diet significantly (p<0.05) increased the serum levels of blood glucose, insulin, total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein (LDL) and very low density lipoprotein cholesterol (VLDLc) with a concomitant reduction in high-density lipoprotein cholesterol (HDLc). These alterations were significantly ameliorated by the extract. High-fructose diet-mediated decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-red) and glucose 6-phosphate dehydrogenase (Glc 6-PD) were significantly (p<0.05) attenuated. Altered levels of glutathione reduced (GSH) and glutathione disulfide (GSSG) were significantly (p<0.05) restored to normal. High-fructose diet-mediated increase in the concentrations of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and percentage fragmented DNA were significantly (p<0.05) lowered by the Hibiscus extract.

CONCLUSION: Overall, aqueous extract of Hibiscus sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose induced metabolic syndrome rats.

Print Options


Sayer Ji
Founder of GreenMedInfo.com

Subscribe to our informative Newsletter & get Nature's Evidence-Based Pharmacy

Our newsletter serves 500,000 with essential news, research & healthy tips, daily.

Download Now

500+ pages of Natural Medicine Alternatives and Information.

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.

© Copyright 2008-2019 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM.