Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in fructose-induced metabolic syndrome rats.
J Sci Food Agric. 2015 May 12. Epub 2015 May 12. PMID: 25965053
T O Ajiboye
BACKGROUND: The effect of Hibiscus sabdariffa calyx extract was evaluated in high-fructose induced metabolic syndrome rats. Insulin resistance, hyperglycemia, dyslipidemia and oxidative rout were induced in rats using high-fructose diet. High-fructose diet-fed rats were administered 100 and 200 mg/kg body weight of Hibiscus sabdariffa extract for 3 weeks, starting from the seventh week of high-fructose diet treatment.
RESULTS: High fructose diet significantly (p<0.05) increased the serum levels of blood glucose, insulin, total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein (LDL) and very low density lipoprotein cholesterol (VLDLc) with a concomitant reduction in high-density lipoprotein cholesterol (HDLc). These alterations were significantly ameliorated by the extract. High-fructose diet-mediated decrease in the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione reductase (GSH-red) and glucose 6-phosphate dehydrogenase (Glc 6-PD) were significantly (p<0.05) attenuated. Altered levels of glutathione reduced (GSH) and glutathione disulfide (GSSG) were significantly (p<0.05) restored to normal. High-fructose diet-mediated increase in the concentrations of malondialdehyde, conjugated dienes, lipid hydroperoxides, protein carbonyl and percentage fragmented DNA were significantly (p<0.05) lowered by the Hibiscus extract.
CONCLUSION: Overall, aqueous extract of Hibiscus sabdariffa palliates insulin resistance, hyperglycemia, dyslipidemia and oxidative rout in high-fructose induced metabolic syndrome rats.