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Abstract Title:

Aqueous extract of Eruca Sativa protects human spermatozoa from mitochondrial failure due to bisphenol A exposure.

Abstract Source:

Reprod Toxicol. 2018 Oct 25 ;82:103-110. Epub 2018 Oct 25. PMID: 30393182

Abstract Author(s):

Dhekra Grami, Kaïs Rtibi, Slimen Selmi, Morad Jridi, Hichem Sebai, Lamjed Marzouki, Iva Sabovic, Carlo Foresta, Luca De Toni

Article Affiliation:

Dhekra Grami

Abstract:

Medicinal plants are suggested to counteract health disorders from chemical pollutants. Here we explored the possible ameliorative effect of Eruca sativa aqueous extract (ESAE) on in vitro acute functional disturbance induced by Bisphenol A (BPA), a disruptor model in human spermatozoa. Phytochemical screening, high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) analysis and 2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]/α,α-diphenyl-β-picrylhydrazyl (ABTS/DPPH) tests disclosed antioxidant properties of ESAE, ascribed to polyphenols and flavonoids. The toxicological impact of BPA on sperm viability and motility was detected for concentration greater than 10 μM but co-incubation with ESAE recovered sperm functionat low concentration (15.62 μg/ml). BPA reduced mitochondrial membrane potential (ΔΨm), with no impact on plasma membrane potential (ΔΨp). At low doses, ESAE recovered ΔΨm but higher doses were associated with impairment of both ΔΨm and ΔΨp. ESAE protects towards in vitro BPA-mediatedtoxicity and its possible use as complementary treatment for male reproductive disorders is critically discussed.

Study Type : Insect Study

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