Apigenin enhances the anti-tumor effect of gemcitabine. - GreenMedInfo Summary
Enhanced anti-tumor effect of combination therapy with gemcitabine and apigenin in pancreatic cancer.
Cancer Lett. 2008 Jan 18;259(1):39-49. Epub 2007 Oct 29. PMID: 17967505
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 110-744, Yeongeon-dong 28, Jongno-gu, Seoul, Republic of Korea.
Apigenin is a dietary flavonoid possessing therapeutic potential against cancers. This study was designed to investigate whether combination therapy with gemcitabine and apigenin enhanced anti-tumor efficacy in pancreatic cancer. In vitro, the combination treatment resulted in more growth inhibition and apoptosis through the down-regulation of NF-kappa B activity with suppression of Akt activation in pancreatic cancer cell lines (MiaPaca-2, AsPC-1). In vivo, the combination therapy augmented tumor growth inhibition through the down-regulation of NF-kappa B activity with the suppression of Akt in tumor tissue. The combination of gemcitabine and apigenin enhanced anti-tumor efficacy through Akt and NF-kappa B activity suppression and apoptosis induction.