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Abstract Title:

Antioxidants do not prevent postexercise peroxidation and may delay muscle recovery.

Abstract Source:

Med Sci Sports Exerc. 2009 Sep ;41(9):1752-60. PMID: 19657294

Abstract Author(s):

Vitor H Teixeira, Hugo F Valente, Susana I Casal, A Franklim Marques, Pedro A Moreira

Article Affiliation:

Faculty of Nutrition and Food Sciences, University of Porto, Porto, Potugal. vhugoteixeira@fcna.up.pt

Abstract:

PURPOSE: This study aimed to determine the effects of 4 wk of antioxidants (AOX) supplementation on exercise-induced lipid peroxidation, muscle damage, and inflammation in kayakers.

METHODS: Subjects (n = 20) were randomly assigned to receive a placebo (PLA) or an AOX capsule (AOX; 272 mg of alpha-tocopherol, 400 mg of vitamin C, 30 mg of beta-carotene, 2 mg of lutein, 400 mug of selenium, 30 mg of zinc, and 600 mg of magnesium). Blood samples were collected at rest and 15 min after a 1000-m kayak race, both before and after the supplementation period, for analysis of alpha-tocopherol, alpha-carotene, beta-carotene, lycopene, lutein plus zeaxanthin, vitamin C, uric acid, total AOX status (TAS), thiobarbituric reactive acid substances (TBARS) and interleukin-6 (IL-6) levels, and creatine kinase (CK), superoxide dismutase (SOD), glutathione reductase (Gr), and glutathione peroxidase (GPx) activities.

RESULTS: With supplementation, plasma alpha-tocopherol (P = 0.003) and beta-carotene (P = 0.007) augmented significantly in the AOX group. IL-6 (exercise, P = 0.039), TBARS (exercise, P<0.001), and uric acid (exercise, P = 0.032) increased significantly in response to the exercise regardless of treatment group. Cortisol level raised more from pre- to postsupplementation period in the PLA group (time x supplementation, P = 0.002). Although TAS declined after exercise before intervention, it increased above preexercise values after the 4-wk period in the AOX group (supplementation x time x exercise, P = 0.034). CK increased after exercise in both groups (exercise effect, P<0.001) and decreased from week 0 to week 4 more markedly in the PLA group (supplementation x time, P = 0.049).

CONCLUSIONS: AOX supplementation does not offer protection against exercise-induced lipid peroxidation and inflammation and may hinder the recovery of muscle damage.

Study Type : Meta Analysis

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