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Article Publish Status: FREE
Abstract Title:

Anticancer Effects of Five Biflavonoids fromL. Male Flowers In Vitro.

Abstract Source:

Molecules. 2019 Apr 16 ;24(8). Epub 2019 Apr 16. PMID: 30995808

Abstract Author(s):

Min Li, Bin Li, Zi-Ming Xia, Ying Tian, Dan Zhang, Wen-Jing Rui, Jun-Xing Dong, Feng-Jun Xiao

Article Affiliation:

Min Li

Abstract:

L., an ancient dioecious gymnosperm, is now cultivated worldwide for landscaping and medical purposes. A novel biflavonoid-amentoflavone 7''-O-β-D-glucopyranoside ()-and four known biflavonoids were isolated and identified from the male flowers of. The anti-proliferative activities of five biflavonoids were evaluated on different cancer lines. Bilobetin () and isoginkgetin () exhibited better anti-proliferative activities on different cancer lines. Their effects were found to be cell-specific and in a dose and time dependent manner for the most sensitive HeLa cells. The significant morphological changes validated their anticancer effects in a dose-dependent manner. They were capable of arresting the G2/M phase of the cell cycle, inducing the apoptosis of HeLa cells dose-dependently and activating the proapoptotic protein Bax and the executor caspase-3. Bilobetin () could also inhibit the antiapoptotic protein Bcl-2. These might be the mechanism underlying their anti-proliferation. In short, bilobetin () and isoginkgetin () might be the early lead compounds for new anticancer agents.

Study Type : In Vitro Study

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