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Abstract Title:

Antibacterial and antibiofilm activities of eugenol from essential oil of Syzygium aromaticum (L.) Merr.&L. M. Perry (clove) leaf against periodontal pathogen Porphyromonas gingivalis.

Abstract Source:

Microb Pathog. 2017 Dec ;113:396-402. Epub 2017 Oct 31. PMID: 29101062

Abstract Author(s):

Yi Zhang, Yue Wang, Xiaojing Zhu, Ping Cao, Shaomin Wei, Yanhua Lu

Article Affiliation:

Yi Zhang

Abstract:

The antibacterial effect and mechanism of eugenol from Syzygium aromaticum (L.) Merr.&L. M. Perry (clove) leaf essential oil (CLEO) against oral anaerobe Porphyromonas gingivalis were investigated. The results showed that eugenol, with content of 90.84% in CLEO, exhibited antibacterial activity against P. gingivalis at a concentration of 31.25 μM. Cell shrink and lysis caused by eugenol were observed with Scanning Electron Microscopy (SEM). The release of macromolecules and uptake of fluorescent dye indicated that the antibacterial activity was due to the ability of eugenol to permeabilize the cell membrane and destroy the integrity ofplasmatic membrane irreversibly. In addition, eugenol inhibited biofilm formation and reduced preformed biofilm of P. gingivalis at different concentrations. The down-regulation of virulence factor genes related to biofilm (fimA, hagA, hagB, rgpA, rgpB, kgp) explained that eugenol suppressed biofilm formation at the initial stage. These findings suggest that eugenol and CLEO may be potential additives in food and personal healthcare products as a prophylactic approach to periodontitis.

Study Type : In Vitro Study

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