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Abstract Title:

Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages.

Abstract Source:

Int J Oncol. 2012 Jan ;40(1):251-60. Epub 2011 Aug 18. PMID: 21874230

Abstract Author(s):

Kaori Takeda, Koh Tomimori, Ryuichiro Kimura, Chie Ishikawa, Tamara K Nowling, Naoki Mori

Article Affiliation:

Department of Microbiology and Oncology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan.

Abstract:

Fucoidan, a sulfated polysaccharide, has significant cytotoxic activity against tumor cells; however, the mechanism(s) of this action remains poorly understood. The present study was designed to determine the in vitro and in vivo effects of fucoidan and their molecular mechanisms. Fucoidan from Cladosiphon okamuranus Tokida cultivated in Okinawa, Japan, delayed tumor growth in Sarcoma 180 (S-180)-bearing mice. However, it failed to inhibit S-180 cell growth in vitro. Activated macrophages are known to have anti-tumor effects. Murine RAW264.7 macrophages stimulated with fucoidan exerted cytotoxicitytowards S-180 cells in vitro. This cytotoxicity was associated with nitric oxide (NO) production. Both cytocidal effect and NO production were significantly inhibited by L-NAME, an inhibitor of NO synthase (NOS). Furthermore, activation of nuclear factor-κB was a key step in the transcriptional activation of the inducible NOS gene. Taken together, our results indicate that the anti-tumor activity of fucoidan on S-180 cells is mediated through increased NO production by fucoidan-stimulated macrophages via nuclear factor-κB-dependent signaling pathway.

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Sayer Ji
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