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Abstract Title:

The Anti-Inflammatory Properties of Terpenoids from.

Abstract Source:

Cannabis Cannabinoid Res. 2018 ;3(1):282-290. Epub 2018 Dec 26. PMID: 30596146

Abstract Author(s):

Ruth Gallily, Zhannah Yekhtin, Lumír Ondřej Hanuš

Article Affiliation:

Ruth Gallily

Abstract:

Cannabinoids are well known to have anti-inflammatory effects in mammalians; however, the Cannabis plant also contains other compounds such as terpenoids, whose biological effects have not yet been characterized. The aim of this study was to compare the anti-inflammatory properties of terpenoids with those of cannabidiol (CBD).Essential oils prepared from three monoecious nonpsychoactive chemotypes of Cannabis were analyzed for their terpenoid content and subsequently studied pharmacologically for their anti-inflammatory propertiesand., the three essential oils rich in terpenoids partly inhibited reactive oxygen intermediate and nitric oxide radical (NO) production in RAW 264.7 stimulated macrophages. The three terpenoid-rich oils exerted moderate anti-inflammatory activities in ananti-inflammatory model without affecting tumor necrosis factor alpha (TNFα) serum levels.The different Cannabis chemotypes showed distinct compositions of terpenoids. The terpenoid-rich essential oils exert anti-inflammatory and antinociceptive activitiesand, which vary according to their composition. Their effects seem to act independent of TNFα. None of the essential oils was as effective as purified CBD. In contrast to CBD that exerts prolonged immunosuppression and might be used in chronic inflammation, the terpenoids showed only a transient immunosuppression and might thus be used to relieve acute inflammation.

Study Type : Animal Study, In Vitro Study

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Sayer Ji
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