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Abstract Title:

Anti-inflammatory effects and corresponding mechanisms of cirsimaritin extracted from Cirsium japonicum var. maackii Maxim.

Abstract Source:

Bioorg Med Chem Lett. 2017 07 15 ;27(14):3076-3080. Epub 2017 May 17. PMID: 28554870

Abstract Author(s):

Myoung-Sook Shin, Jun Yeon Park, Jaemin Lee, Hye Hyun Yoo, Dae-Hyun Hahm, Sang Cheon Lee, Sanghyun Lee, Gwi Seo Hwang, Kiwon Jung, Ki Sung Kang

Article Affiliation:

Myoung-Sook Shin

Abstract:

In this study, we investigated the anti-inflammatory effects and mechanisms of cirsimaritin isolated from an ethanol extract of the aerial parts of Cirsium japonicum var. maackii Maxim. using RAW264.7 cells. The extract and its flavonoid cirsimaritin inhibited nitric oxide (NO) production and inducible nitric oxide synthase expression in RAW264.7 cells. Cirsimaritin inhibited interleukin-6, tumor necrosis factor-α, and NO production in a concentration-dependent manner in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. From a western blot study, pretreatment with cirsimaritin inhibited phosphorylation/degradation of IκBα and phosphorylation of Akt in LPS-stimulated RAW264.7 cells. Moreover, cirsimaritin suppressed activation of LPS-induced transcription factors, such as c-fos and signal transducer and activator of transcription 3 (STAT3), in RAW264.7 cells. Collectively, these results show that cirsimaritin possesses anti-inflammatory activity, which is regulated by inhibition of c-fos and STAT3phosphorylation in RAW264.7 cells.

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