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Article Publish Status: FREE
Abstract Title:

Anti-Inflammatory Activity ofExtracts: AnStudy on Porcine Aortic Endothelial Cells.

Abstract Source:

Oxid Med Cell Longev. 2018 ;2018:2504305. Epub 2018 Jun 25. PMID: 30046370

Abstract Author(s):

Martina Bertocchi, Gloria Isani, Federica Medici, Giulia Andreani, Irvin Tubon Usca, Paola Roncada, Monica Forni, Chiara Bernardini

Article Affiliation:

Martina Bertocchi

Abstract:

This study is aimed at investigating the cytotoxicity, anti-inflammatory, and angiogenic activities of twoextracts on primary culture of porcine aortic endothelial cells (pAECs). Chemical characterization of a dry extract (extract A) and a hydroenzymatic extract (extract G) ofwas performed by HPLC using pure boswellic acids (BAs) as standard. In cultured pAECs, extract G improved cell viability, following LPS challenge, in a dose-dependent manner and did not show any toxic effect. On the other hand, extract A was toxic at higher doses and restored pAEC viability after LPS challenge only at lower doses. Pure BAs, used at the same concentrations as those determined in the phytoextracts, did not contrast LPS-induced cytotoxicity. Extract A showed proangiogenic properties at the lowest dose, and the same result was observed using pure AKBA at the corresponding concentration, whereas extract G did not show any effect on the migration capacity of endothelial cells. In conclusion, an anti-inflammatory activity ofextracts on endothelial cells was reported, though cytotoxicity or proliferative stimulation can occur instead of a protective effect, depending on the dose and the formulation.

Study Type : In Vitro Study

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Sayer Ji
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