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Article Publish Status: FREE
Abstract Title:

Anti-glycating and anti-oxidant compounds from traditionally used anti-diabetic plant Geigeria alata(DC) Oliv.&Hiern.

Abstract Source:

Nat Prod Res. 2019 Feb 7:1-9. Epub 2019 Feb 7. PMID: 30732466

Abstract Author(s):

Eltayeb Fadul, Arsalan Nizamani, Saima Rasheed, Achyut Adhikari, Sammer Yousuf, Shahida Parveen, Nezhun Gören, Hassan A Alhazmi, M Iqbal Choudhary, Asaad Khalid

Article Affiliation:

Eltayeb Fadul

Abstract:

A new sesquiterpene lactone geigerianoloide (1) and four known flavonoids axillarin (2), quercetin (3), 3-methoxy-5,7,3',4'-tetrahydroxy-flavone (4) and hispidulin (5) were isolated from Geigeria alata (DC) Oliv.&Hiern. (Asteraceae). Structures were deduced usingH- andC- NMR spectroscopy, mass spectrometry, while the structure of compound 1 was also deduced using X-ray crystallography technique. Geigeria alata is traditionally used for diabetes, therefore compounds were tested for anti-glycation activity, in which compounds 2 and 3 showed potent activities (ICvalues of 246.97 ± 0.83 and 262.37 ± 0.22 µM, respectively) compared to ICvalue 294.50 ± 1.5 µM of rutin. Moreover, compound 4 exhibited a comparable activity to rutin (IC = 293.28 ± 1.34 µM). Compound 5 showed a weak activity. Compounds 2, 3, and 4 exhibited potent DPPH radical scavenging activity (IC = 0.1 ± 0.00, 0.13 ± 0.00 and 0.15 ± 0.01 µM, respectively). Compounds 2, 3, and 4 demonstrated significant superoxide anion scavenging activity with ICvalues of 0.14 ± 0.001, 0.17 ± 0.00, and 0.11 ± 0.006 µM, respectively.

Study Type : In Vitro Study

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Sayer Ji
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