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Abstract Title:

[Effect of angelica polysaccharides co-erythropoietin on JAK2/STAT5 signal transduction pathway in hematopoietic stem/progenitor cells].

Abstract Source:

Zhongguo Zhong Yao Za Zhi. 2009 Dec;34(24):3268-71. PMID: 20353016

Abstract Author(s):

Zisen Hua, Shudan Song, Chunyan Luo, Jianwei Wang, Yaping Wang

Article Affiliation:

Laboratory of Stem Cell and Tissue Engineering, Chongqing Medical University, Chongqing 400016, China. zisen526@yahoo.cn

Abstract:

OBJECTIVE: To investgate the signal transduction and regulation in erythropoiesis by angelica polysaccharides (APS) to clarify the mechanism for APS promoting hematopoiesis.

METHOD: The mononuclear cells were isolated from foetus umbilic cord blood (mononuclear cells, MNCs), after MNCs were incubated in the presence of APS group (APS 200 mg x L(-1)) and control group for 24 h, the cells were stimulated with Epo (5 U x mL(-1)) for 0, 2, 5, 30 min, respectively. STAT5 was measured by ICC and laser confocal scanning microscope. JAK2, STAT5 in nucleus and cytoplasm were measured by western-blotting-ECL.

RESULT: Angelica polysaccharide cooperated with Epo has significant impact on the expression of STAT5. The expression of STAT5 has significant difference between APS group and the control group at 4 time points. JAK2, STAT5 expressed in cytoplasm and nuclear of APS group significantly increased as compared to those of control group, and they expressed the strongest at 5 min.

CONCLUSION: JAK2, STAT5 signal transduction molecule plays an important role in the effect of APS cooperated with Epo on promoting hematopoiesis.

Study Type : In Vitro Study

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