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Article Publish Status: FREE
Abstract Title:

Allicin alleviates lead-induced hematopoietic stem cell aging by upregulating PKM2.

Abstract Source:

Biosci Rep. 2019 Jun 18. Epub 2019 Jun 18. PMID: 31213573

Abstract Author(s):

Shi-Zhong Cai, Li-Na Zhao, Jun Liu, Yi-Ting Ji, Xiao-Yan Shi, Zhou-Rui Ma, Xiao-Hua Lv, Ke Chen, Yan Chen

Article Affiliation:

Shi-Zhong Cai

Abstract:

Hematopoietic stem cells (HSCs) aging is associated with hematopoietic dysfunction and diseases. Our previous study showed that lead exposure induced a functional decline in HSCs. Allicin, a chemical extracted from the garlic (), has been reported to have anti-oxidative and anti-inflammatory effects. However, the biological activities of allicin on lead-induced toxicity, especially in the hematopoietic system, remain unclear. Here, we found that lead exposure elicited aging phenotypes in HSCs, including perturbed cell quiescence, disabled self-renewal function and colony forming ability, and myeloid-biased differentiation, all of which contributed to significant hematopoietic disorders in mice. Intragastric administration of allicin substantially ameliorated lead-induced HSCs aging phenotypeslead exposure induced a peroxide condition in HSCs leading to DNA damage, which reduced expression of the glycolytic enzyme pyruvate kinase M2 isoform (PKM2), a phenotype which was significantly ameliorated by allicin treatment. These findings suggested that allicin alleviated lead-induced HSCs aging by upregulating PKM2 expression; thus, it could be a natural herb for preventing lead toxicity.

Study Type : In Vitro Study
Additional Links
Pharmacological Actions : Cytoprotective : CK(190) : AC(94)
Problem Substances : Lead : CK(167) : AC(32)

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