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Abstract Title:

The lifespan-promoting effect of acetic acid and Reishi polysaccharide.

Abstract Source:

Bioorg Med Chem.2009 Nov 15;17(22):7831-40. Epub 2009 Sep 6. PMID: 19837596

Abstract Author(s):

Ming-Hong Chuang, Shyh-Horng Chiou, Chun-Hao Huang, Wen-Bin Yang, Chi-Huey Wong

Abstract:

Using Caenorhabditis elegans as a model organism, various natural substances and commercial health-food supplements were screened to evaluate their effects on longevity. Among the substances tested, acetic acid and Reishi polysaccharide fraction 3 (RF3) were shown to increase the expression of the lifespan and longevity-related transcription factor DAF-16 in C. elegans. We have shown that RF3 activates DAF-16 expression via TIR-1 receptor and MAPK pathway whereas acetic acid inhibits the trans-membrane receptor DAF-2 of the insulin/IGF-1 pathway to indirectly activate DAF-16 expression. In addition, a mixture of acetic acid and RF3 possesses a combined effect 30-40% greater than either substance used alone. A proteomic analysis of C. elegans using 2-DE and LC-MS/MS was then carried out, and 15 differentially expressed proteins involved in the lifespan-promoting activity were identified.

Study Type : Animal Study

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Sayer Ji
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