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Article Publish Status: FREE
Abstract Title:

6-Gingerol reduces Pseudomonas aeruginosa biofilm formation and virulence via quorum sensing inhibition.

Abstract Source:

Sci Rep. 2015 ;5:8656. Epub 2015 Mar 2. PMID: 25728862

Abstract Author(s):

Han-Shin Kim, Sang-Hoon Lee, Youngjoo Byun, Hee-Deung Park

Article Affiliation:

Han-Shin Kim

Abstract:

Pseudomonas aeruginosa is a well-known pathogenic bacterium that forms biofilms and produces virulence factors via quorum sensing (QS). Interfering with normal QS interactions between signal molecules and their cognate receptors is a developing strategy for attenuating its virulence. Here we tested the hypothesis that 6-gingerol, a pungent oil of fresh ginger, reduces biofilm formation and virulence by antagonistically binding to P. aeruginosa QS receptors. In silico studies demonstrated molecular binding occurs between 6-gingerol and the QS receptor LasR through hydrogen bonding and hydrophobic interactions. Experimentally 6-gingerol reduced biofilm formation, several virulence factors (e.g., exoprotease, rhamnolipid, and pyocyanin), and mice mortality. Further transcriptome analyses demonstrated that 6-gingerol successfully repressed QS-induced genes, specifically those related to the production of virulence factors. These results strongly support our hypothesis and offer insight into the molecular mechanism that caused QS gene repression.

Study Type : In Vitro Study

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Sayer Ji
Founder of GreenMedInfo.com

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